Hvad betyder "AUC" Mean in Chemotherapy?

Hvad betyder

Kemoterapi er designet til at dræbe kræftceller. Men når den når en høj koncentration i kroppen, kan den begynde at angribe normale, sunde celler. Det er derfor meget vigtigt at overvåge niveauet af kemoterapeutiske lægemidler i blodet. Område under kurven (AUC) er en matematisk metode til måling af lægemiddelkoncentrationer.

OmrĂĄde under kurven

Den "kurve", der er omtalt i AUC, er kurven på en koncentration-versus-time-graf. Koncentrationen af ​​et lægemiddel i patientens blod er tegnet mod den tid, hvor prøven blev taget. Området under denne kurve måles med basisberegningen.

Calvert Formel

Kalverformlen anvendes almindeligvis til at bestemme den bedste dosis kemoterapeutisk lægemiddel til en patient. Det hedder, at dosis er lig med det ønskede AUC multipliceret med patientens glomerulære filtreringshastighed (GFR). GFR er et mål for, hvor hurtigt en patient eliminerer stoffet fra hans krop.

Kliniske anvendelser

Kalverformlen anvendes til bestemmelse af dosis af kemoterapeutiske lægemidler, såsom 5-fluorouracil og carboplatin. AUC er et hurtigt mål for, hvor meget af stoffet et individ har været udsat for i en given tid. At holde AUC inden for et bestemt område hjælper med at begrænse de farlige bivirkninger af kemoterapi.
Hvad betyder

FAQ - 💬

❓ What does AUC dosing mean?

👉 In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.

❓ What does increased AUC mean?

👉 The AUC is inversely proportional to the clearance of the drug. That is, the higher the clearance, the less time the drug spends in the systemic circulation and the faster the decline in the plasma drug concentration.

❓ What is AUC in clinical trials?

👉 The area under the curve (AUC) is a summary measure that integrates serial assessments of a patient's endpoint over the duration of the study.

❓ How is drug AUC calculated?

👉 1:298:53How to Calculate AUCStart of suggested clipEnd of suggested clipAnd can be represented by 1 over the quantity clearance. Over volume this then simplifies to doseMoreAnd can be represented by 1 over the quantity clearance. Over volume this then simplifies to dose over clearance as the area under the curve. This equation is very simple and very useful.

❓ What is a good AUC score?

👉 between 0.8-0.9The area under the ROC curve (AUC) results were considered excellent for AUC values between 0.9-1, good for AUC values between 0.8-0.9, fair for AUC values between 0.7-0.8, poor for AUC values between 0.6-0.7 and failed for AUC values between 0.5-0.6.

❓ What is AUC in drug sensitivity?

👉 The area under the curve (AUC) calculated from time zero to infinity following drug administration is an important PK parameter that measures the patient's “exposure” to a drug and depends on dose, bioavailability, and clearance [6].

❓ What is a good AUC?

👉 In general, an AUC of 0.5 suggests no discrimination (i.e., ability to diagnose patients with and without the disease or condition based on the test), 0.7 to 0.8 is considered acceptable, 0.8 to 0.9 is considered excellent, and more than 0.9 is considered outstanding.

❓ What does an AUC of 0.65 mean?

👉 0.5-0.7 = Poor discrimination. 0.7-0.8 = Acceptable discrimination. 0.8-0.9= Excellent discrimination. >0.9 = Outstanding discrimination.

❓ What does AUC of 0.5 mean?

👉 This ROC curve has an AUC of 0.5, meaning it ranks a random positive example higher than a random negative example 50% of the time. As such, the corresponding classification model is basically worthless, as its predictive ability is no better than random guessing.

❓ Why do we use AUC for Carboplatin?

👉 Maximum Carboplatin Dose Calculation3 The FDA has recommended that physicians consider capping the dose of carboplatin for desired exposure (AUC) to avoid potential toxicity due to overdosing. The maximum dose is based on a GFR estimate that is capped at 125 mL/min for patients with normal renal function.

❓ What AUC value is good?

👉 The area under the ROC curve (AUC) results were considered excellent for AUC values between 0.9-1, good for AUC values between 0.8-0.9, fair for AUC values between 0.7-0.8, poor for AUC values between 0.6-0.7 and failed for AUC values between 0.5-0.6.

❓ What does “AUC” mean in cancer?

👉 What Does “AUC” Mean in Chemotherapy? Chemotherapy is designed to kill cancerous cells. However, when it reaches a high concentration in the body it can begin to attack normal, healthy cells. It is therefore very important to monitor the level of chemotherapeutic drugs in the blood. Area Under the Curve (AUC) is a mathematical method ...

❓ What is area under the curve (AUC) in chemotherapy?

👉 Chemotherapy is designed to kill cancerous cells. However, when it reaches a high concentration in the body it can begin to attack normal, healthy cells. It is therefore very important to monitor the level of chemotherapeutic drugs in the blood. Area Under the Curve (AUC) is a mathematical method of measuring drug concentrations.

❓ What is the target AUC value for chemotherapy?

👉 This is said to be a more specific method than that of dosing based on body surface area. Target AUC usually has values around 4-7 mg/ml/min in clinical practice for already treated patients but for those without previous chemotherapy sessions the target should revolve around 6-8 mg/ml/min.

❓ How is the area under the blood concentration-time curve (AUC) calculated?

👉 The area under the blood concentration-time curve (AUC) of CBDCA was calculated by Calvert's formula for 111 of the 115 patients. A retrospective study was conducted to define the relationship between the clinical outcome of the combination chemotherapy and the AUC of CBDCA. The overall response rate was 58.4% in the 115 patients.

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